Antimicrobial and antiviral activity of porphyrin photosensitization

Zvi Malik; Hava Ladan; Yeshayahu Nitzan; Zehava Smetana

doi:10.1117/12.168668

1 March 1994 Antimicrobial and antiviral activity of porphyrin photosensitization

Zvi Malik, Hava Ladan, Yeshayahu Nitzan, Zehava Smetana

Proceedings Volume 2078, Photodynamic Therapy of Cancer; (1994) https://doi.org/10.1117/12.168668
Event: Europto Biomedical Optics '93, 1993, Budapest, Hungary

Abstract

In order to photosensitize Gram (-) bacteria such as Pseudomonas aeuruginosa and Escherichia coli, we introduced the small peptide polymyxin-B nona-peptide (PBNP) which stimulated the translocation of porphyrin through the outer membrane of these bacteria and makes PDT possible. Gram negative cell killing by the use of PBNP and DP broadens the antibacterial spectrum of photodynamic inactivation and opens new horizons for this modality as a wide spectrum drug when antibiotic resistance is the main concern. Plasmidial and chromosomal DNA damage in S. aureus and E. coli cells was mediated by DP photosensitization. The major observation was the disappearance of the plasmid supercoiled fraction. The chromosomal DNA was also affected and its degradation products were detected after treatment.

Citation Download Citation

Zvi Malik, Hava Ladan, Yeshayahu Nitzan, and Zehava Smetana "Antimicrobial and antiviral activity of porphyrin photosensitization", Proc. SPIE 2078, Photodynamic Therapy of Cancer, (1 March 1994); https://doi.org/10.1117/12.168668

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