Prospects of radical-interacting porphyrin photosensitizers and their possible use in photodynamic therapy

Dezso Gal; T Shuliakovskaya; Tamas Vidoczy; Saleh Elzemzam; Gabor Vasvari; L. Suemegi; Zsolt Kuti

doi:10.1117/12.168684

1 March 1994 Prospects of radical-interacting porphyrin photosensitizers and their possible use in photodynamic therapy

Dezso Gal, T Shuliakovskaya, Tamas Vidoczy, Saleh Elzemzam, Gabor Vasvari, L. Suemegi, Zsolt Kuti

Proceedings Volume 2078, Photodynamic Therapy of Cancer; (1994) https://doi.org/10.1117/12.168684
Event: Europto Biomedical Optics '93, 1993, Budapest, Hungary

Abstract

Based on literature data obtained in various fields with respect to studies on the role of free radicals in biology and on the kinetics of triplet-doublet interactions, it is suggested that excited photosensitizers react in vivo with free radicals formed in malignant tissues during photodynamic therapy (PDT) and this interaction competes with sensitizer-radical + molecule and the singlet oxygen mediated effects. Experimental results by laser flash photolysis and electron spin resonance revealed that sensitizer applied in PDT react with stable free radicals presumably both by energy transfer and electron transfer.

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Dezso Gal, T Shuliakovskaya, Tamas Vidoczy, Saleh Elzemzam, Gabor Vasvari, L. Suemegi, and Zsolt Kuti "Prospects of radical-interacting porphyrin photosensitizers and their possible use in photodynamic therapy", Proc. SPIE 2078, Photodynamic Therapy of Cancer, (1 March 1994); https://doi.org/10.1117/12.168684

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