Differentiation of artery wall lesions using porphyrins and fiberoptic sensor in rabbits

Sandor G. Vari M.D.; Maurits J. van der Veen; Theodore G. Papazoglou; Michael C. Fishbein M.D.; Marigo Stavridi; Thanassis Papaioannou; Warren S. Grundfest M.D.

doi:10.1117/12.169112

15 February 1994 Differentiation of artery wall lesions using porphyrins and fiberoptic sensor in rabbits

Sandor G. Vari M.D., Maurits J. van der Veen, Theodore G. Papazoglou, Michael C. Fishbein M.D., Marigo Stavridi, Thanassis Papaioannou, Warren S. Grundfest M.D.

Author Affiliations +

Proceedings Volume 2086, Medical Applications of Lasers; (1994) https://doi.org/10.1117/12.169112
Event: Europto Biomedical Optics '93, 1993, Budapest, Hungary

Abstract

We investigated the ability of fluorescence spectroscopy, and photosensitizers to differentiate normal, hyperplastic and atherosclerotic arterial wall lesions in vivo. Hyperplastic lesions were induced in the abdominal aorta (AB) of 24 rabbits by balloon injury (BI). Atherosclerotic arterial wall lesions were induced by BI and diet. Fluorescence signals from thoracic n equals 16 and AB n equals 15 sites were analyzed by computer. A ratio was used as an index of drug presence. Use of PPS or BPD and LIFS may be a feasible, in vivo method for the differentiation between normal, hyperplastic and atherosclerotic arterial wall lesions.

Citation Download Citation

Sandor G. Vari M.D., Maurits J. van der Veen, Theodore G. Papazoglou, Michael C. Fishbein M.D., Marigo Stavridi, Thanassis Papaioannou, and Warren S. Grundfest M.D. "Differentiation of artery wall lesions using porphyrins and fiberoptic sensor in rabbits", Proc. SPIE 2086, Medical Applications of Lasers, (15 February 1994); https://doi.org/10.1117/12.169112

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