Light delivery and dosimetry for photodynamic therapy in an ovarian-cancer mouse model

Lothar D. Lilge; W. Dabrowski; David W. Holdsworth; J. Blake; D. Kato; Brian C. Wilson; Tayyaba Hasan

doi:10.1117/12.179978

19 July 1994 Light delivery and dosimetry for photodynamic therapy in an ovarian cancer mouse model

Lothar D. Lilge, W. Dabrowski, David W. Holdsworth, J. Blake, D. Kato, Brian C. Wilson, Tayyaba Hasan

Proceedings Volume 2133, Optical Methods for Tumor Treatment and Detection: Mechanisms and Techniques in Photodynamic Therapy III; (1994) https://doi.org/10.1117/12.179978
Event: OE/LASE '94, 1994, Los Angeles, CA, United States

Abstract

The Swiss nude mouse model is currently used as an animal model to investigate the efficacy of photodynamic therapy in ovarian cancer treatment. The disease requires treatment illumination of the entire abdominal cavity. The close proximity of the internal organs in the abdomen of a mouse and the vastly different optical properties of these organs present a challenge to light delivery and dosimetry. In this study the efficacy of different internal and transcutaneous light delivery geometries was investigated by scanning a transverse plane of the peritoneum with optical fiber fluence-rate detectors. The placement of the implanted optical fibers in the abdominal cavity was verified post mortem in selected animals by high resolution CT imaging. Preliminary experiments were performed to correlate the biological response with actual total fluence delivered to the abdominal cavity. Optical fiber fluence rate detectors were implanted in the peritoneum and abdominal cavity and the animal was treated with PDT. Cell survival of one hour post light treatment harvested cells from the peritoneum was used as a biological response quantifier.

Citation Download Citation

Lothar D. Lilge, W. Dabrowski, David W. Holdsworth, J. Blake, D. Kato, Brian C. Wilson, and Tayyaba Hasan "Light delivery and dosimetry for photodynamic therapy in an ovarian cancer mouse model", Proc. SPIE 2133, Optical Methods for Tumor Treatment and Detection: Mechanisms and Techniques in Photodynamic Therapy III, (19 July 1994); https://doi.org/10.1117/12.179978

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