Feasibility of using high-speed electron beam x-ray CT to follow the time course of the pulmonary response to pneumonectomy in rabbits

L. E. Olson; V. P. Wright; Eric A. Hoffman

doi:10.1117/12.174408

1 May 1994 Feasibility of using high-speed electron beam x-ray CT (EBCT) to follow the time course of the pulmonary response to pneumonectomy in rabbits

L. E. Olson, V. P. Wright, Eric A. Hoffman

Author Affiliations +

Proceedings Volume 2168, Medical Imaging 1994: Physiology and Function from Multidimensional Images; (1994) https://doi.org/10.1117/12.174408
Event: Medical Imaging 1994, 1994, Newport Beach, CA, United States

Abstract

This report focuses on preliminary experiments designed to determine regional blood flows and air, blood, and tissue contents at end expiratory lung volume in anesthetized, paralyzed, normal, sham-operated, and pneumonectomized (left lung removed) rabbits with and without wax plombage. High temporal resolution measurements were made with an EBCT scanner during the mechanical injection of a bolus of radiopaque contrast material into the pulmonary vasculature. The time-intensity curves of selected lung regions were analyzed with VIDA^R using a modification of the myocardial blood flow model proposed by Wolfkiel et al. The resulting data provided an estimate of regional blood flow and total and regional air, blood and `tissue' contents, where `tissue' represents intracellular and interstitial water, i.e., lung water exclusive of blood. The estimates of mean lung air, blood and tissue contents were similar across groups and consistent with anticipated results.

Citation Download Citation

L. E. Olson, V. P. Wright, and Eric A. Hoffman "Feasibility of using high-speed electron beam x-ray CT (EBCT) to follow the time course of the pulmonary response to pneumonectomy in rabbits", Proc. SPIE 2168, Medical Imaging 1994: Physiology and Function from Multidimensional Images, (1 May 1994); https://doi.org/10.1117/12.174408

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