Automated headspace analysis for quality assurance of pharmaceutical vials by laser Raman spectroscopy

A. S. Gilbert; K. W. Hobbs; A. H. Reeves; P. P. Jobson

doi:10.1117/12.194342

15 November 1994 Automated head-space analysis for quality assurance of pharmaceutical vials by laser Raman spectroscopy

A. S. Gilbert, K. W. Hobbs, A. H. Reeves, P. P. Jobson

Author Affiliations +

Proceedings Volume 2248, Optical Measurements and Sensors for the Process Industries; (1994) https://doi.org/10.1117/12.194342
Event: Optics for Productivity in Manufacturing, 1994, Frankfurt, Germany

Abstract

We have constructed a fully automated Raman spectroscopic headspace gas analyzer for the assaying of oxygen and nitrogen in sealed vials. A single grating spectrograph with pre-filter and multichannel detection is utilized. Visible radiation at 488 nanometers is obtained from an argon ion laser. It is used to inspect vials containing a pharmaceutical product which is freeze dried and sealed under nitrogen (N₂). This product, though buffered, is sensitive to carbon dioxide (CO₂); therefore the analyzer is utilized to reject vials which have suffered ingress of air by detecting the presence of oxygen (O₂).

Citation Download Citation

A. S. Gilbert, K. W. Hobbs, A. H. Reeves, and P. P. Jobson "Automated head-space analysis for quality assurance of pharmaceutical vials by laser Raman spectroscopy", Proc. SPIE 2248, Optical Measurements and Sensors for the Process Industries, (15 November 1994); https://doi.org/10.1117/12.194342

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