Variability and covariability in magnetic resonance functional neuroimaging

Nicholas Lange

doi:10.1117/12.179246

8 July 1994 Variability and covariability in magnetic resonance functional neuroimaging

Nicholas Lange

Proceedings Volume 2299, Mathematical Methods in Medical Imaging III; (1994) https://doi.org/10.1117/12.179246
Event: SPIE's 1994 International Symposium on Optics, Imaging, and Instrumentation, 1994, San Diego, CA, United States

Abstract

Geometric statistical reasoning is useful for addressing variability and covariability in quantitative analyses of functional neuroimaging experiments. General image smoothness, i.e., intrinsic temporal and spatial autocorrelation, must be accommodated adequately in order to obtain reliable statistical inferences and meaningful practical conclusions. Several exploratory displays and models for such images in the temporal, spatial and spectral domains are summarized. These tools are applicable in functional magnetic resonance imaging, positron emission tomography and other modalities that produce spatial time series. Construction of an objective binary mask that excludes irrevelant voxels from the search volume increases statistical power. Further improvements in sensitivity and consistency are possible when intrasubject replications are available. A recent experiment that uses functional magnetic resonance imaging to detect focal activations significantly cross-correlated with a designed mental arithmetic task demonstrates the utility of these techniques.

Citation Download Citation

Nicholas Lange "Variability and covariability in magnetic resonance functional neuroimaging", Proc. SPIE 2299, Mathematical Methods in Medical Imaging III, (8 July 1994); https://doi.org/10.1117/12.179246

ACCESS THE FULL ARTICLE

INSTITUTIONAL
Select your institution to access the SPIE Digital Library.

SELECT YOUR INSTITUTION

PERSONAL
Sign in with your SPIE account to access your personal subscriptions or to use specific features such as save to my library, sign up for alerts, save searches, etc.

PERSONAL SIGN IN

No SPIE Account? Create one

PURCHASE THIS CONTENT

SUBSCRIBE TO DIGITAL LIBRARY

50 downloads per 1-year subscription

Members: $195

Non-members: $335 ADD TO CART

25 downloads per 1 - year subscription

Members: $145

Non-members: $250 ADD TO CART

PURCHASE SINGLE ARTICLE

Includes PDF, HTML & Video, when available