Medical applications of MIR-fiber spectroscopic probes

Vjacheslav G. Artioushenko; Natalia I. Afanasyeva; Alexander A. Lerman; Alexander P. Kryukov; E. F. Kuzin; Natalia N. Zharkova; Victor G. Plotnichenko; George A. Frank; G. I. Didenko; Victor V. Sokolov; Wolfgang Neuberger

doi:10.1117/12.182118

5 August 1994 Medical applications of MIR-fiber spectroscopic probes

Vjacheslav G. Artioushenko, Natalia I. Afanasyeva, Alexander A. Lerman, Alexander P. Kryukov, E. F. Kuzin, Natalia N. Zharkova, Victor G. Plotnichenko, George A. Frank, G. I. Didenko, Victor V. Sokolov, Wolfgang Neuberger

Author Affiliations +

Proceedings Volume 2321, Second International Conference on Optoelectronic Science and Engineering '94; (1994) https://doi.org/10.1117/12.182118
Event: Optoelectronic Science and Engineering '94: International Conference, 1994, Beijing, China

Abstract

During last years polycrystalline AgBrCI1 fibers (so-called MIR-fibers) were under close investigation with the goal to use them as remote fiberoptic spectroscopic sensors (1 ,2]. These fibers are transparent in 4 - 1 6 pm range, where the most of fundamental vibrations are placed. The synergy of FTIR-spectrometers with flexible remote fiber sensor offers in some cases major advantages over standard spectroscopic technique. Due to the high level of the absorption in the middle infrared region of most organic compounds the use of evanescent field sensor, where the fiber is used as an attenuated total reflection (ATR) sensing element, is more convenient. Easy remote contact with investigated samples is the another reason to use evanescent type of sensor. In this paper such evanescent fiberoptic sensor combined with FTIR spectrometer is used for cancer diagnostics of tissues. It is well-known now that the structure and composition modifications in malignant tissues lead to associated changes in absorption spectra of tissues [3,4]. Tissue spectra measurements in vitro were made in a set of experiments. One of the main advantage of such technique is that it get possibility of in vivo cancer or some other deceases spectroscopic diagnostics, which could enrich non-invasive methods in clinical diagnostics. These experiments were mainly performed to realize in vivo measurements in future. High flexibility and nontoxicity provide possibility to use this fibers for this purpose in standard or specially constructed endoscopes. The main serious handicap to that study is the complexity of real tissue spectra analysis.

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Vjacheslav G. Artioushenko, Natalia I. Afanasyeva, Alexander A. Lerman, Alexander P. Kryukov, E. F. Kuzin, Natalia N. Zharkova, Victor G. Plotnichenko, George A. Frank, G. I. Didenko, Victor V. Sokolov, and Wolfgang Neuberger "Medical applications of MIR-fiber spectroscopic probes", Proc. SPIE 2321, Second International Conference on Optoelectronic Science and Engineering '94, (5 August 1994); https://doi.org/10.1117/12.182118

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