Influence of photodynamic therapy on the delay of metastasis development in Lewis lung carcinoma

Vanya Mantareva; Kroum Kassabov; Maria Shopova; Silke Muller; Dieter Woehrle

doi:10.1117/12.199167

12 January 1995 Influence of photodynamic therapy on the delay of metastasis development in Lewis lung carcinoma

Vanya Mantareva, Kroum Kassabov, Maria Shopova, Silke Muller, Dieter Woehrle

Proceedings Volume 2325, Photodynamic Therapy of Cancer II; (1995) https://doi.org/10.1117/12.199167
Event: International Symposium on Biomedical Optics Europe '94, 1994, Lille, France

Abstract

As it is known the tumor model Lewis lung carcinoma (LLC) is inclined to form metastases very early after its implantation. Although photodynamic therapy (PDT) of tumors is a local method, we studied its influence on the development of lung metastases in LLC bearing C57B1/6 mice after tumor implantation. The used photosensitizer was a newly synthesized Zn(II)-naphthalocyanine (tetrabenzylamidotetranaphtho (2, 3-b:2', 3'-g: 2', 3' - 1:2'', 3''-q) porphyrazinatozinc) incorporated into DPPC-liposomes and excited with monochromatic light at its absorption maximum (lambda) _exc 774 nm). The appearance of metastases in the animal lungs was evaluated according to the method of Pal, et al. Fourteen days after LLC implantation the tumor diameter for the treated mice was 6 mm (a week after PDT) towards 13.6 mm for the untreated. The percentage of surviving animals was 100 for the treated towards 0 for the untreated (a month after the implantation). Fourteen days after LLC implantation only 25% from the treated animals developed metastases to 75% from the untreated. The summary metastasis volume was 4.5 times smaller for the treated than the untreated mice. In conclusion we consider that the used Zn(II)-naphthalocyanine could be an effective photosensitizer for LLC treatment and although the PDT-method is a local one it could influence the process of metastasis development.

Citation Download Citation

Vanya Mantareva, Kroum Kassabov, Maria Shopova, Silke Muller, and Dieter Woehrle "Influence of photodynamic therapy on the delay of metastasis development in Lewis lung carcinoma", Proc. SPIE 2325, Photodynamic Therapy of Cancer II, (12 January 1995); https://doi.org/10.1117/12.199167

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