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23 December 1994 Photodynamic therapy of contractile arterial smooth muscle cells in vivo using aluminium disulphonated phthalocyanine: implications for angioplasty-induced intimal hyperplasia
Isaac Nyamekye, Jean R. McEwan, Alexander J. MacRobert, Christopher C. R. Bishop, Stephen G. Bown
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Proceedings Volume 2327, Medical Applications of Lasers II; (1994) https://doi.org/10.1117/12.197580
Event: International Symposium on Biomedical Optics Europe '94, 1994, Lille, France
Abstract
Photodynamic therapy (PDT) of proliferative vascular smooth muscle cells (SMC) reduces intimal hyperplasia. We asses the effects of PDT on contractile SMC In normal arteries using aluminum disulphonated phthalocyanine (AlS2Pc) sensitization. Rats sensitized with intravenous AlS2Pc underwent carotid artery fluorescence measurement. More rats had carotid artery irradiation with different laser energies 30 minutes after sensitization with AlS2Pc 5.0 mg/kg and sacrificed at 3 days. Additional rats were irradiated with 50 J/cm2 after sensitization with different AlS2Pc doses and sacrificed at 3 and 14 days. Histological analysis was by light microscopy. Rats treated with PDT and sacrificed at 3 and 6 months were also analyzed. The results show AlS2Pc induced high and dose dependent fluorescence within the arterial media. All PDT light doses (50 - 250 J/cm2) produced arterial SMC depletion. In contrast, PDT sensitizer doses produced complete cell depletion only at high doses of AlS2Pc. These treated arteries were acellular after 3 days. At 14 days the media remained acellular but the endothelial lining regenerated. The arterial media remained acellular even at 6 months -- however, no hemorrhage, thrombosis or aneurysm formation was seen. Arterial PDT causes media contractile SMC depletion in vivo and the artery retains its structural and functional integrity.
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Isaac Nyamekye, Jean R. McEwan, Alexander J. MacRobert, Christopher C. R. Bishop, and Stephen G. Bown "Photodynamic therapy of contractile arterial smooth muscle cells in vivo using aluminium disulphonated phthalocyanine: implications for angioplasty-induced intimal hyperplasia", Proc. SPIE 2327, Medical Applications of Lasers II, (23 December 1994); https://doi.org/10.1117/12.197580
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KEYWORDS
Photodynamic therapy
Arteries
Luminescence
Aluminum
In vivo imaging
Laser applications
Medical laser equipment
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