Regulation of photosensitizing activity of chlorin e6 derivatives in biosystems

S. N. Charankevich; Vladimir P. Zorin; Tatyana E. Zorina; Ivan I. Khludeyev; Iosif S. Mikhalovsky

doi:10.1117/12.197443

2 January 1995 Regulation of photosensitizing activity of chlorin e₆ derivatives in biosystems

S. N. Charankevich, Vladimir P. Zorin, Tatyana E. Zorina, Ivan I. Khludeyev, Iosif S. Mikhalovsky

Proceedings Volume 2370, 5th International Conference on Laser Applications in Life Sciences; (1995) https://doi.org/10.1117/12.197443
Event: Laser Applications in Life Sciences: 5th International Conference, 1994, Minsk, Belarus

Abstract

The mechanisms of cellular uptake of the photosensitizers chlorin e₆, chlorin e₆ trimethylester and chlorin e₆ ethylendiamid are reported in this paper. Each photosensitizer cellular uptake mechanism was determined by preferentially inhibiting the process of low-density lipoprotein (LDL) binding to cells and endocytosis by chilling cellular cultures or by the action of metabolic inhibitors or heparin. The results indicate that delivery with LDL plays a significant role in the process of pigment accumulation by tumor cells. At the same time chlorin e₆ derivatives uptake is only partly mediated by receptor dependence endocytosis of LDL. The involvement of molecular diffusion exchange into the binding of apolar chlorin e₆ derivatives to cells is suggested.

Citation Download Citation

S. N. Charankevich, Vladimir P. Zorin, Tatyana E. Zorina, Ivan I. Khludeyev, and Iosif S. Mikhalovsky "Regulation of photosensitizing activity of chlorin e₆ derivatives in biosystems", Proc. SPIE 2370, 5th International Conference on Laser Applications in Life Sciences, (2 January 1995); https://doi.org/10.1117/12.197443

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