Photodynamic therapy in early esophageal squamous cell carcinoma

Pasquale Spinelli; Marco Dal Fante; Andrea Mancini; Renato Massetti; Emmanuele Meroni

doi:10.1117/12.203428

1 March 1995 Photodynamic therapy in early esophageal squamous cell carcinoma

Pasquale Spinelli, Marco Dal Fante, Andrea Mancini, Renato Massetti, Emmanuele Meroni

Proceedings Volume 2371, 5th International Photodynamic Association Biennial Meeting; (1995) https://doi.org/10.1117/12.203428
Event: Fifth International Photodynamic Association Biennial Meeting, 1994, Amelia Island, FL, United States

Abstract

From 1/1985 to 7/1993, 18 patients underwent endoscopic photodynamic therapy (PDT) for early stage esophageal squamous cell carcinoma -- as two patients had two synchronous esophageal cancers, 20 lesions were treated. Tumors were staged as Tis in 7 cases and T1 in 13. The average light energy delivered was 50 J/cm² and 70 J/cm² for the treatment of Tis and T1, respectively. To obtain a more uniform distribution of laser light in 12 cases the irradiation was performed through the wall of a transparent tube previously placed over the endoscope and advanced into the stomach. The overall results show a complete response in 14/20 (70%) tumors. Three patients developed a local recurrence, 6, 12, and 14 months after therapy. After a follow-up of 5 to 75 months, there was no evidence of disease in 10/18 patients (56%). The actuarial survival rate was 95%, 79%, and 26% at 1, 3, and 5 years, respectively. Complications were skin reaction in one patient and esophageal stenosis at the treatment site, that gradually responded to endoscopic bougienage, in 2 patients. Endoscopic PDT proved to be safe and effective in the treatment of superficial carcinoma of the esophagus.

Citation Download Citation

Pasquale Spinelli, Marco Dal Fante, Andrea Mancini, Renato Massetti, and Emmanuele Meroni "Photodynamic therapy in early esophageal squamous cell carcinoma", Proc. SPIE 2371, 5th International Photodynamic Association Biennial Meeting, (1 March 1995); https://doi.org/10.1117/12.203428

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