Photodynamic therapy of normal canine prostate

Qun Chen; Sugandh D. Shetty M.D.; Brian C. Wilson; Michael S. Patterson; Larry Heads; Daniel Schultz; Joseph C. Cerny M.D.; H. Chen; Fred W. Hetzel

doi:10.1117/12.203386

1 March 1995 Photodynamic therapy of normal canine prostate

Qun Chen, Sugandh D. Shetty M.D., Brian C. Wilson, Michael S. Patterson, Larry Heads, Daniel Schultz, Joseph C. Cerny M.D., H. Chen, Fred W. Hetzel

Author Affiliations +

Proceedings Volume 2371, 5th International Photodynamic Association Biennial Meeting; (1995) https://doi.org/10.1117/12.203386
Event: Fifth International Photodynamic Association Biennial Meeting, 1994, Amelia Island, FL, United States

Abstract

To provide basic scientific information for utilizing photodynamic therapy to treat prostatic carcinoma, PDT dosimetry and effective treatment volume were investigated using canine prostate as an in vivo animal model. The prostate glands were surgically exposed. Isotropic tip fibers were inserted into the gland for either light irradiation or detection. PDT doses of 400 J and 1, 3 or 5 mg/kg Photofrin were used for single fiber irradiation treatments. All animals were terminated at 1 week and the prostates evaluated histopathologically. The results show that the lesion size was dependent on the treatment dose. The maximum lesion dimension was approximately 1.6 cm. The data acquired from the single fiber irradiation study were then used to plan for multi-fiber interstitial PDT treatments with a goal of achieving a larger treatment volume for practical purpose. The data indicate that the lesion size from the multiple fiber treatment could be predicted based on the single fiber treatment with the light pattern summed from all sources.

Citation Download Citation

Qun Chen, Sugandh D. Shetty M.D., Brian C. Wilson, Michael S. Patterson, Larry Heads, Daniel Schultz, Joseph C. Cerny M.D., H. Chen, and Fred W. Hetzel "Photodynamic therapy of normal canine prostate", Proc. SPIE 2371, 5th International Photodynamic Association Biennial Meeting, (1 March 1995); https://doi.org/10.1117/12.203386

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