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30 May 1995 Dosimetry for photodynamic therapy of endometrial tissue
Lars Othar Svaasand, Mathias K. Fehr, Sten Madsen, Yona Tadir M.D., Bruce J. Tromberg
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Proceedings Volume 2389, Optical Tomography, Photon Migration, and Spectroscopy of Tissue and Model Media: Theory, Human Studies, and Instrumentation; (1995) https://doi.org/10.1117/12.210002
Event: Photonics West '95, 1995, San Jose, CA, United States
Abstract
Hysterectomy is the most common major operation performed in the United States with dysfunctional uterine bleeding as one of the major indications. The clinical needs for simple and safe endometrial destruction are essential. Photodynamic therapy (PDT) may offer a simple and cost effective solution for the treatment of dysfunctional uterine bleeding. The dosimetry is discussed for the case of topical application of photosensitizer. This technique might be the method of preference because undesired side effects such as skin photosensitization that is typical for systemically injected photosensitizers, can be avoided. Effective PDT requires a sufficient amount of light delivered to the targeted tissue in a reasonable period of time. A trifurcated optical applicator consisting of three cylindrical diffusing fibers has been constructed, and this applicator can deliver a typical required optical dose of about 50-100 J/cm2 to the full depth of the endometrium for an exposure time of 10-20 minutes.
© (1995) COPYRIGHT Society of Photo-Optical Instrumentation Engineers (SPIE). Downloading of the abstract is permitted for personal use only.
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Lars Othar Svaasand, Mathias K. Fehr, Sten Madsen, Yona Tadir M.D., and Bruce J. Tromberg "Dosimetry for photodynamic therapy of endometrial tissue", Proc. SPIE 2389, Optical Tomography, Photon Migration, and Spectroscopy of Tissue and Model Media: Theory, Human Studies, and Instrumentation, (30 May 1995); https://doi.org/10.1117/12.210002
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KEYWORDS
Tissue optics
Photodynamic therapy
Optical fibers
Diffusion
Scattering
Uterus
Light scattering
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