Fluorescence photodiagnosis for malignant tumor

Tetsuya Okunaka; Kinya Furukawa M.D.; Kouichi Tanaka; Hideaki Shimatani; Masahiko Harada; Hiroshi Shibuya; Shinya Okada; Jitsuo Usuda; Chimori Konaka; Katsuo Aizawa; Harubumi Kato M.D.

doi:10.1117/12.237525

2 April 1996 Fluorescence photodiagnosis for malignant tumor

Tetsuya Okunaka, Kinya Furukawa M.D., Kouichi Tanaka, Hideaki Shimatani, Masahiko Harada, Hiroshi Shibuya, Shinya Okada, Jitsuo Usuda, Chimori Konaka, Katsuo Aizawa, Harubumi Kato M.D.

Author Affiliations +

Proceedings Volume 2675, Optical Methods for Tumor Treatment and Detection: Mechanisms and Techniques in Photodynamic Therapy V; (1996) https://doi.org/10.1117/12.237525
Event: Photonics West '96, 1996, San Jose, CA, United States

Abstract

The effectiveness of a new excimer laser endoscopic imaging fluorescence analyzer system using the photosensitizer, mono-L-aspartyl chlorin e6 (NPe6) for the detection of tumors was evaluated. Autofluorescence (550 plus or minus 10 nm, green fluorescence) from normal sites, red fluorescence (664 nm) of NPe6 in areas of cancer and the red fluorescence/green fluorescence ratio (R/G ratio) as the color image can be detected respectively. The greatest NPe6 fluorescence from the lesion was obtained at 3 hours after injection and the fluorescence disappeared at 24 hours. The greatest difference in the fluorescence of NPe6 and the R/G ratio in areas of tumor and in normal areas were observed at 5 hours after administration. At this period, NPe6 fluorescence from normal sites was negligible. These data suggest that fluorescence photodiagnosis may be effective in the detection of cancers.

Citation Download Citation

Tetsuya Okunaka, Kinya Furukawa M.D., Kouichi Tanaka, Hideaki Shimatani, Masahiko Harada, Hiroshi Shibuya, Shinya Okada, Jitsuo Usuda, Chimori Konaka, Katsuo Aizawa, and Harubumi Kato M.D. "Fluorescence photodiagnosis for malignant tumor", Proc. SPIE 2675, Optical Methods for Tumor Treatment and Detection: Mechanisms and Techniques in Photodynamic Therapy V, (2 April 1996); https://doi.org/10.1117/12.237525

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