Laser Doppler flowmetry in photodynamic therapy on xenotransplanted tumors

Anja Vervoorts; H. Achim Rood; Joerg G. Moser; Marcus Klotz

doi:10.1117/12.239531

10 May 1996 Laser Doppler flowmetry in photodynamic therapy on xenotransplanted tumors

Anja Vervoorts, H. Achim Rood, Joerg G. Moser, Marcus Klotz

Proceedings Volume 2678, Optical Diagnostics of Living Cells and Biofluids; (1996) https://doi.org/10.1117/12.239531
Event: Photonics West '96, 1996, San Jose, CA, United States

Abstract

Perfusion of tumor tissue is a necessary prerequisite for radiotherapy and Photodynamic Tumor Therapy (PDT). For PDT perfusion means oxygen supply to a light activated photosensitizing drug inside tumor cells to destroy these cells specifically by light activated singlet oxygen. These experiments are normally done in rodents, but can be much more easily performed on tumors transplanted to the extraembryonal painfree vessels developed during chick embryogenesis. We chose the yolk sac membrane (YSM) and the chorioallantoic membrane (CAM) for quantitative blood flow measurements. Near infrared light (830 nm) was used for measurements in vascularized xenotransplanted tumors on the extraembryonal membranes because at this wavelength blood flow can be detected also in vessels covered by tumor cells. We measured the influences on blood flow of different photosensitizers with and without therapeutic irradiation and single components of a polyphasic PDT System.

Citation Download Citation

Anja Vervoorts, H. Achim Rood, Joerg G. Moser, and Marcus Klotz "Laser Doppler flowmetry in photodynamic therapy on xenotransplanted tumors", Proc. SPIE 2678, Optical Diagnostics of Living Cells and Biofluids, (10 May 1996); https://doi.org/10.1117/12.239531

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