Laser desorption mass spectrometry for molecular diagnosis

C. H. Winston Chen; N. I. Taranenko; Y. F. Zhu; S. L. Allman; K. Tang; K. J. Matteson; L. Y. Chang; C. N. Chung; Steve Martin; Lawrence Haff

doi:10.1117/12.237634

1 April 1996 Laser desorption mass spectrometry for molecular diagnosis

C. H. Winston Chen, N. I. Taranenko, Y. F. Zhu, S. L. Allman, K. Tang, K. J. Matteson, L. Y. Chang, C. N. Chung, Steve Martin, Lawrence Haff

Author Affiliations +

Proceedings Volume 2680, Ultrasensitive Biochemical Diagnostics; (1996) https://doi.org/10.1117/12.237634
Event: Photonics West '96, 1996, San Jose, CA, United States

Abstract

Laser desorption mass spectrometry has been used for molecular diagnosis of cystic fibrosis. Both 3-base deletion and single-base point mutation have been successfully detected by clinical samples. This new detection method can possibly speed up the diagnosis by one order of magnitude in the future. It may become a new biotechnology technique for population screening of genetic disease.

Citation Download Citation

C. H. Winston Chen, N. I. Taranenko, Y. F. Zhu, S. L. Allman, K. Tang, K. J. Matteson, L. Y. Chang, C. N. Chung, Steve Martin, and Lawrence Haff "Laser desorption mass spectrometry for molecular diagnosis", Proc. SPIE 2680, Ultrasensitive Biochemical Diagnostics, (1 April 1996); https://doi.org/10.1117/12.237634

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