Factor analysis for spillover correction or movement detection in dynamic PET studies

Han-Ming Wu; Carl K. Hoh; Sung-Cheng Huang

doi:10.1117/12.237866

8 April 1996 Factor analysis for spillover correction or movement detection in dynamic PET studies

Han-Ming Wu, Carl K. Hoh, Sung-Cheng Huang

Proceedings Volume 2709, Medical Imaging 1996: Physiology and Function from Multidimensional Images; (1996) https://doi.org/10.1117/12.237866
Event: Medical Imaging 1996, 1996, Newport Beach, CA, United States

Abstract

In this study, we applied factor analysis of dynamic structures (FADS) techniques in dynamic PET images to (1) extract the arterial time activity curve (TAC) from human adult or small monkey dynamic FDG PET; and (2) investigate the use of FADS generated factor images and factor curves to detect large subject movements during dynamic GA-68 EDTA scans of brain tumor patients. The results showed that a blood sample constraint improved the accuracy of FADS technique in extracting the `pure' blood pool TAC from dynamic PET studies that have large spillover problems. The studies of GA-68 EDTA brain PET studies showed that three major factors were extracted from images using FADS. For studies with little patient movement, a standard pattern of three factor curves and three factor images were obtained. However, large patient movement changed the outcomes of FADS results. We conclude that (1) FADS technique with a blood sample allows the extraction of the `pure' blood pool TAC directly from quantitative PET images without requiring multiple blood samples, region-of- interest drawing or spillover correction; and (2) FADS technique provides a sensitive way to detect large patient movements in dynamic PET studies.

Citation Download Citation

Han-Ming Wu, Carl K. Hoh, and Sung-Cheng Huang "Factor analysis for spillover correction or movement detection in dynamic PET studies", Proc. SPIE 2709, Medical Imaging 1996: Physiology and Function from Multidimensional Images, (8 April 1996); https://doi.org/10.1117/12.237866

ACCESS THE FULL ARTICLE

INSTITUTIONAL
Select your institution to access the SPIE Digital Library.

SELECT YOUR INSTITUTION

PERSONAL
Sign in with your SPIE account to access your personal subscriptions or to use specific features such as save to my library, sign up for alerts, save searches, etc.

PERSONAL SIGN IN

No SPIE Account? Create one

PURCHASE THIS CONTENT

SUBSCRIBE TO DIGITAL LIBRARY

50 downloads per 1-year subscription

Members: $195

Non-members: $335 ADD TO CART

25 downloads per 1 - year subscription

Members: $145

Non-members: $250 ADD TO CART

PURCHASE SINGLE ARTICLE

Includes PDF, HTML & Video, when available