Application of DNQ-based microlithography to patterning bioactive molecules and cells

Dan V. Nicolau; Takahisa Taguchi; Hiroshi Taniguchi; Susumu Yoshikawa; Mircea V. Dusa

doi:10.1117/12.241848

14 June 1996 Application of DNQ-based microlithography to patterning bioactive molecules and cells

Dan V. Nicolau, Takahisa Taguchi, Hiroshi Taniguchi, Susumu Yoshikawa, Mircea V. Dusa

Proceedings Volume 2724, Advances in Resist Technology and Processing XIII; (1996) https://doi.org/10.1117/12.241848
Event: SPIE's 1996 International Symposium on Microlithography, 1996, Santa Clara, CA, United States

Abstract

Photochemically induced surface functionality manipulation of Diazo-Naphto-Quinone/novolak polymeric films was used for controlling the specificity of the attachment and growth of neuronal cells and biologically active molecules (proteins and peptides) patterning. Different microlithographic techniques (standard positive tone, negative tone image reversal based on catalyzed decarboxylation, positive tone of image reversal resist, and surface imaging based on silylation), controlling the surface hydrophobicity and surface concentration of carboxylic groups, were assessed in the view of the suitability as microlithographic techniques for patterning biologically active molecules and cells. It was found that DNQ-based materials and techniques can be easily transferred in bio-microlithography, which is the building of laterally ordered architectures with biological structural elements.

Citation Download Citation

Dan V. Nicolau, Takahisa Taguchi, Hiroshi Taniguchi, Susumu Yoshikawa, and Mircea V. Dusa "Application of DNQ-based microlithography to patterning bioactive molecules and cells", Proc. SPIE 2724, Advances in Resist Technology and Processing XIII, (14 June 1996); https://doi.org/10.1117/12.241848

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