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The aim of photodynamic diagnosis is the complete visualization of all neoplastic lesions in a tumorous organ after topical or systemic application of a tumor selective photosensitizer. In this investigation we performed quantitative fluorescence measurements following topical and systemic application of 5-aminolevulinic acid to head and neck tumors. We investigated 15 patients with neoplastic lesions of the oral cavity and 5 patients with carcinoma of the larynx after rinsing a 0.4 percent-5-ALA solution or inhalation 5 percent-5-ALA. One patient was given 5-ALA systemically p.o. in a concentration of 10mg/kg b.w. Time course and type of porphyrin accumulation were analyzed in neoplastic and surrounding normal tissue by measuring emission spectra of ALA-induced protoporphyrin IX fluorescence at regular intervals for up to 3 hours following 15 minutes of continuous rinsing of a 0.4 percent- ALA-solution, 1 hour of continuous inhalation and 3 hours after p.o. application. After excitation with violet light of a high pressure xenon arc lamp, fluorescence images in the red spectral range from the tumor tissue and the corresponding macroscopic visible tumor were recorded with a CCD-camera. A quantitative analysis of the fluorescence contrast in neoplastic and surrounding tissue was performed using an optical multichannel analyzer.
Andreas Leunig,Kai Rick,Herbert G. Stepp,Ralph Gutmann,Alwin E. Goetz,Reinhold Baumgartner, andJens Feyh
"Fluorescence photodetection of head and neck cancer following topical or systemic application of 5-aminolevulinic acid", Proc. SPIE 2922, Laser Applications in Medicine and Dentistry, (3 December 1996); https://doi.org/10.1117/12.260713
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Andreas Leunig, Kai Rick, Herbert G. Stepp, Ralph Gutmann, Alwin E. Goetz, Reinhold Baumgartner, Jens Feyh, "Fluorescence photodetection of head and neck cancer following topical or systemic application of 5-aminolevulinic acid," Proc. SPIE 2922, Laser Applications in Medicine and Dentistry, (3 December 1996); https://doi.org/10.1117/12.260713