Intravesical dosimetry applied to laser positioning in photodynamic therapy

Guillaume Beslon; Philippe Ambroise; Bernard Heit; Jacques Bremont; Francois H. Guillemin

doi:10.1117/12.260782

4 December 1996 Intravesical dosimetry applied to laser positioning in photodynamic therapy

Guillaume Beslon, Philippe Ambroise, Bernard Heit, Jacques Bremont, Francois H. Guillemin

Proceedings Volume 2924, Photochemotherapy: Photodynamic Therapy and Other Modalities II; (1996) https://doi.org/10.1117/12.260782
Event: BiOS Europe '96, 1996, Vienna, Austria

Abstract

Superficial bladder tumor is a challenging indication for photodynamic therapy. Due to lack of specificity of the sensitizers, the light has to be precisely monitored over the bladder surface, illuminated by an isotropic source, to restrict the cytotoxic effect to the tumor without affecting the normal epithelium. In order to assist the surgeon while processing the therapy, an urothelium illumination model is proposed. It is computed through a spline interpolation, on the basis of 12 intravesical sensors. This paper presents the overall system architecture and details the modelization and visualization processes. With this model, the surgeon is able to master the source displacement inside the bladder and to homogenize the tissue exposure.

Citation Download Citation

Guillaume Beslon, Philippe Ambroise, Bernard Heit, Jacques Bremont, and Francois H. Guillemin "Intravesical dosimetry applied to laser positioning in photodynamic therapy", Proc. SPIE 2924, Photochemotherapy: Photodynamic Therapy and Other Modalities II, (4 December 1996); https://doi.org/10.1117/12.260782

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