Comparison of numerical simulations and laboratory studies of laser thrombolysis

Edward J. Chapyak; Robert P. Godwin; Scott A. Prahl; HanQun Shangguan

doi:10.1117/12.275023

22 May 1997 Comparison of numerical simulations and laboratory studies of laser thrombolysis

Edward J. Chapyak, Robert P. Godwin, Scott A. Prahl, HanQun Shangguan

Proceedings Volume 2970, Lasers in Surgery: Advanced Characterization, Therapeutics, and Systems VII; (1997) https://doi.org/10.1117/12.275023
Event: BiOS '97, Part of Photonics West, 1997, San Jose, CA, United States

Abstract

We compare Los Alamos numerical simulations with Oregon Medical Laser Center laser deposition experiments conducted with gelatin thrombus surrogates specifically chosen for relevance to clinical laser thrombolysis. Initial idealized calculations suggest that a surprisingly large fraction of the absorbed laser energy appears as acoustic radiation. We build on these results here by investigating geometrical affects, material property variations, and sources of dissipation including viscosity and plastic flow, as well as acoustic radiation, in an effort to explain flow effects observed in the experiments. In particular, strong jetting is observed in the simulations when the gelatin is given a kinematic viscosity in excess of approximately 1.0 cm²/s. Jetting is clearly evident in the experiments.

Citation Download Citation

Edward J. Chapyak, Robert P. Godwin, Scott A. Prahl, and HanQun Shangguan "Comparison of numerical simulations and laboratory studies of laser thrombolysis", Proc. SPIE 2970, Lasers in Surgery: Advanced Characterization, Therapeutics, and Systems VII, (22 May 1997); https://doi.org/10.1117/12.275023

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