In vivo argon laser vascular welding using thermal feedback: open- and closed-loop patency and collagen crosslinking

Ward Small IV; Peter M. Celliers; George E. Kopchok M.D.; Karen M. Reiser; Nicholas J. Heredia; Duncan J. Maitland; David C. Eder; Richard A. London; Mauricio Heilbron; Farabi Hussain; Rodney A. White M.D.; Luiz Barroca Da Silva; Dennis L. Matthews

doi:10.1117/12.275050

22 May 1997 In-vivo argon laser vascular welding using thermal feedback: open- and closed-loop patency and collagen crosslinking

Ward Small IV, Peter M. Celliers, George E. Kopchok M.D., Karen M. Reiser, Nicholas J. Heredia, Duncan J. Maitland, David C. Eder, Richard A. London, Mauricio Heilbron, Farabi Hussain, Rodney A. White M.D., Luiz Barroca Da Silva, Dennis L. Matthews

Author Affiliations +

Proceedings Volume 2970, Lasers in Surgery: Advanced Characterization, Therapeutics, and Systems VII; (1997) https://doi.org/10.1117/12.275050
Event: BiOS '97, Part of Photonics West, 1997, San Jose, CA, United States

Abstract

An in vivo study of vascular welding with a fiber-delivered argon laser was conducted using a canine model. Longitudinal arteriotomies and venotomies were treated on femoral vein and artery. Laser energy was delivered to the vessel wall via a 400 micrometer optical fiber. The surface temperature at the center of the laser spot was monitored in real time using a hollow glass optical fiber-based two-color infrared thermometer. The surface temperature was limited by either a room-temperature saline drip or direct feedback control of the laser using a mechanical shutter to alternately pass and block the laser. Acute patency was evaluated either visually (leak/no leak) or by in vivo burst pressure measurements. Biochemical assays were performed to investigate the possible laser-induced formation or destruction of enzymatically mediated covalent crosslinks between collagen molecules. Viable welds were created both with and without the use of feedback control. Tissues maintained at 50 degrees Celsius using feedback control had an elevated crosslink count compared to controls, while those irradiated without feedback control experienced a decrease. Differences between the volumetric heating associated with open and closed loop protocols may account for the different effects on collagen crosslinks. Covalent mechanisms may play a role in argon laser vascular fusion.

Citation Download Citation

Ward Small IV, Peter M. Celliers, George E. Kopchok M.D., Karen M. Reiser, Nicholas J. Heredia, Duncan J. Maitland, David C. Eder, Richard A. London, Mauricio Heilbron, Farabi Hussain, Rodney A. White M.D., Luiz Barroca Da Silva, and Dennis L. Matthews "In-vivo argon laser vascular welding using thermal feedback: open- and closed-loop patency and collagen crosslinking", Proc. SPIE 2970, Lasers in Surgery: Advanced Characterization, Therapeutics, and Systems VII, (22 May 1997); https://doi.org/10.1117/12.275050

ACCESS THE FULL ARTICLE

INSTITUTIONAL
Select your institution to access the SPIE Digital Library.

SELECT YOUR INSTITUTION

PERSONAL
Sign in with your SPIE account to access your personal subscriptions or to use specific features such as save to my library, sign up for alerts, save searches, etc.

PERSONAL SIGN IN

No SPIE Account? Create one

PURCHASE THIS CONTENT

SUBSCRIBE TO DIGITAL LIBRARY

50 downloads per 1-year subscription

Members: $195

Non-members: $335 ADD TO CART

25 downloads per 1 - year subscription

Members: $145

Non-members: $250 ADD TO CART

PURCHASE SINGLE ARTICLE

Includes PDF, HTML & Video, when available