Frequency domain fluorescence optical imaging using a finite element method

Yaling Pei; Yuqi Yao; Feng-Bao Lin; Randall Locke Barbour

doi:10.1117/12.280243

18 August 1997 Frequency domain fluorescence optical imaging using a finite element method

Yaling Pei, Yuqi Yao, Feng-Bao Lin, Randall Locke Barbour

Proceedings Volume 2979, Optical Tomography and Spectroscopy of Tissue: Theory, Instrumentation, Model, and Human Studies II; (1997) https://doi.org/10.1117/12.280243
Event: BiOS '97, Part of Photonics West, 1997, San Jose, CA, United States

Abstract

In this paper, a reconstruction algorithm for fluorescence yield and lifetime imaging in dense scattering media is formulated and implemented. Two frequency domain radiation transport equations based on the diffusion approximation are used to model the migration of excitation and emitted photons. In the forward formulation, a finite element approach, which is specially effective for complex geometries and inhomogeneous distribution of medium properties, is adopted to obtain the required imaging operator and the simulated detector responses related to the photon fluxes on the boundary. Inverse formulation is derived based on the integral form of two diffusion equations. The technique is demonstrated by reconstructing spatial images of heterogenous fluorophore distribution and life time using simulated data obtained from homogeneous and complex (i.e., MRI breast map) media containing objects with fluorophore and with and without added noise.

Citation Download Citation

Yaling Pei, Yuqi Yao, Feng-Bao Lin, and Randall Locke Barbour "Frequency domain fluorescence optical imaging using a finite element method", Proc. SPIE 2979, Optical Tomography and Spectroscopy of Tissue: Theory, Instrumentation, Model, and Human Studies II, (18 August 1997); https://doi.org/10.1117/12.280243

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