In-vivo tissue measurements with optical low-coherence tomography

Eva Lankenau; Julia Welzel; Reginald Birngruber; Ralf Engelhardt

doi:10.1117/12.274299

22 May 1997 In-vivo tissue measurements with optical low-coherence tomography

Eva Lankenau, Julia Welzel, Reginald Birngruber, Ralf Engelhardt

Proceedings Volume 2981, Coherence Domain Optical Methods in Biomedical Science and Clinical Applications; (1997) https://doi.org/10.1117/12.274299
Event: BiOS '97, Part of Photonics West, 1997, San Jose, CA, United States

Abstract

Optical low coherence tomography (OCT) is a promising new method for non invasive, in vivo measurements of biological high scattering tissue. Crossectional images with microscale resolution in a range of about 1 5tm can be produced. A scanning point detection system is realized which combines an interferometric method with an endoscope. A superluminescence diode with a center wavelength of 830nm and a coherence length of l5jtm is coupled into the interferometrical setup. The backscattered light from a tissue sample and the reflected light from the scanning reference mirror is recombined at the detector. Interference occurs only if the pathlength difference is within the coherence length of the light source. Heterodyne detection is used to obtain high speed and high dynamic range measurements of the interferometric signals. We present in vivo OCT skin measurements, where we analyze the borders between the upper skin layers. We describe the influence to the light attenuation inside the skin after treating the skin with oil. We compare in vivo OCT skin measurements with in vitro skin measurements. Additionally first in vivo skin measurements of malignant melanoma show that OCT is a promising diagnostic method in dermatology. Keywords: skin cancer, optical coherence tomography, in vivo skin measurements, endoscope

Citation Download Citation

Eva Lankenau, Julia Welzel, Reginald Birngruber, and Ralf Engelhardt "In-vivo tissue measurements with optical low-coherence tomography", Proc. SPIE 2981, Coherence Domain Optical Methods in Biomedical Science and Clinical Applications, (22 May 1997); https://doi.org/10.1117/12.274299

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