Development and validation of technique for in-vivo 3D analysis of cranial bone graft survival

Mark P. Bernstein; Curtis B. Caldwell; Oleh M. Antonyshyn; Karen Ma; Perry W. Cooper; Lisa E. Ehrlich

doi:10.1117/12.274072

9 May 1997 Development and validation of technique for in-vivo 3D analysis of cranial bone graft survival

Mark P. Bernstein, Curtis B. Caldwell, Oleh M. Antonyshyn, Karen Ma, Perry W. Cooper, Lisa E. Ehrlich

Author Affiliations +

Proceedings Volume 3033, Medical Imaging 1997: Physiology and Function from Multidimensional Images; (1997) https://doi.org/10.1117/12.274072
Event: Medical Imaging 1997, 1997, Newport Beach, CA, United States

Abstract

Bone autografts are routinely employed in the reconstruction of facial deformities resulting from trauma, tumor ablation or congenital malformations. The combined use of post- operative 3D CT and SPECT imaging provides a means for quantitative in vivo evaluation of bone graft volume and osteoblastic activity. The specific objectives of this study were: (1) Determine the reliability and accuracy of interactive computer-assisted analysis of bone graft volumes based on 3D CT scans; (2) Determine the error in CT/SPECT multimodality image registration; (3) Determine the error in SPECT/SPECT image registration; and (4) Determine the reliability and accuracy of CT-guided SPECT uptake measurements in cranial bone grafts. Five human cadaver heads served as anthropomorphic models for all experiments. Four cranial defects were created in each specimen with inlay and onlay split skull bone grafts and reconstructed to skull and malar recipient sites. To acquire all images, each specimen was CT scanned and coated with Technetium doped paint. For purposes of validation, skulls were landmarked with 1/16-inch ball-bearings and Indium. This study provides a new technique relating anatomy and physiology for the analysis of cranial bone graft survival.

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Mark P. Bernstein, Curtis B. Caldwell, Oleh M. Antonyshyn, Karen Ma, Perry W. Cooper, and Lisa E. Ehrlich "Development and validation of technique for in-vivo 3D analysis of cranial bone graft survival", Proc. SPIE 3033, Medical Imaging 1997: Physiology and Function from Multidimensional Images, (9 May 1997); https://doi.org/10.1117/12.274072

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KEYWORDS

Bone

Single photon emission computed tomography

Computed tomography

Head

Skull

3D image processing

Image registration

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