Autoradiographic-based phantoms for emission tomography

Gene R. Gindi; Doug Dougherty; Ing-Tsung Hsiao; Anand Rangarajan

doi:10.1117/12.274126

25 April 1997 Autoradiographic-based phantoms for emission tomography

Gene R. Gindi, Doug Dougherty, Ing-Tsung Hsiao, Anand Rangarajan

Author Affiliations +

Proceedings Volume 3034, Medical Imaging 1997: Image Processing; (1997) https://doi.org/10.1117/12.274126
Event: Medical Imaging 1997, 1997, Newport Beach, CA, United States

Abstract

In the development of reconstruction algorithms in emission computed tomography (ECT), digital phantoms designed to mimic the presumed spatial distribution of radionuclide activity in a human are extensively used. Given the low spatial resolution in ECT, it is usually presumed that a crude phantom, usually with a constant activity level within an anatomically derived region, is sufficiently realistic for testing. Here, we propose that phantoms may be improved by assigning biologically realistic patterns of activity in more precisely delineated regions. Animal autoradiography is proposed as a source of realistic activity and anatomy. We discus the basics of radiopharmaceutical autoradiography and discuss aspects of using such data for a brain phantom. A few crude simulations with brain phantoms derived from animal data are shown.

Citation Download Citation

Gene R. Gindi, Doug Dougherty, Ing-Tsung Hsiao, and Anand Rangarajan "Autoradiographic-based phantoms for emission tomography", Proc. SPIE 3034, Medical Imaging 1997: Image Processing, (25 April 1997); https://doi.org/10.1117/12.274126

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