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29 December 1997 PDT of Barrett's esophagus: kinetics and localization of 5-aminolevulinic acid-induced porphyrin accumulation in the rat esophagus
Jolanda van den Boogert, Richard van Hillegersberg, Adriaan B. Houtsmuller, Peter D. Siersema, Ron W. F. de Bruin, Hugo W. Tilanus
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Proceedings Volume 3191, Photochemotherapy: Photodynamic Therapy and Other Modalities III; (1997) https://doi.org/10.1117/12.297822
Event: BiOS Europe '97, 1997, San Remo, Italy
Abstract
Photodynamic therapy (PDT) with 5-aminolevulinic acid (ALA)- induced photosensibilization may be used to selectively eliminate Barrett's epithelium. To find optimal treatment parameters, the kinetics, localization and mechanism of ALA- induced protoporphyrin IX (PpIX) accumulation in rat oesophagus were studied. After a single dose of ALA (200 mg/kg i.v. or oral), porphyrin accumulation in the mucosa was 3.4 fold higher than in the muscularis, with a maximum at 3 hours after ALA administration. Enzyme measurements showed a higher ratio of PBGD:ferrochelatase in mucosa. In conclusion, the rat oesophageal mucosa can be selectively photosensitized with PpIX after a single dose of ALA, with a peak concentration at 3 hours. Selectivity may be caused by the higher PBGD:ferrochelatase ratio. This makes ALA most suitable for PDT treatment of Barrett's oesophagus.
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Jolanda van den Boogert, Richard van Hillegersberg, Adriaan B. Houtsmuller, Peter D. Siersema, Ron W. F. de Bruin, and Hugo W. Tilanus "PDT of Barrett's esophagus: kinetics and localization of 5-aminolevulinic acid-induced porphyrin accumulation in the rat esophagus", Proc. SPIE 3191, Photochemotherapy: Photodynamic Therapy and Other Modalities III, (29 December 1997); https://doi.org/10.1117/12.297822
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KEYWORDS
Esophagus
Photodynamic therapy
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