Tumor detection with cyanine dye poly(ethylene glycol) conjugates as contrast agents for near-infrared imaging

Bjoern Riefke; Kai Licha; Dirk Nolte; Bernd Ebert; Herbert H. Rinneberg; Wolfhard Semmler

doi:10.1117/12.297924

13 January 1998 Tumor detection with cyanine dye poly(ethylene glycol) conjugates as contrast agents for near-infrared imaging

Bjoern Riefke, Kai Licha, Dirk Nolte, Bernd Ebert, Herbert H. Rinneberg, Wolfhard Semmler

Author Affiliations +

Proceedings Volume 3196, Optical and Imaging Techniques for Biomonitoring III; (1998) https://doi.org/10.1117/12.297924
Event: BiOS Europe '97, 1997, San Remo, Italy

Abstract

The influence of the molecular weight of cyanine dye- poly(ethylene glycol) (PEG) conjugates on their pharmacokinetic behavior and on the contrast between malignant and normal tissue in fluorescence images was studied. PEG conjugates with a molecular weight ranging from 1800 to 40000 g mol^-1 were investigated in a rat model. A tunable, pulsed, solid-state laser system and an intensified CCD camera served to record fluorescence images of different tumor-bearing mice and rats. The time window of increased contrast between tumor and normal tissue in fluorescence images can be adjusted by the molecular weigh of PEG residues. Furthermore, we were able to demonstrate the visualization of subcutaneous blood vessels.

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Bjoern Riefke, Kai Licha, Dirk Nolte, Bernd Ebert, Herbert H. Rinneberg, and Wolfhard Semmler "Tumor detection with cyanine dye poly(ethylene glycol) conjugates as contrast agents for near-infrared imaging", Proc. SPIE 3196, Optical and Imaging Techniques for Biomonitoring III, (13 January 1998); https://doi.org/10.1117/12.297924

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