Chronology of healing events in pulsed CO2 laser skin resurfacing in fuzzy rat

Sharon L. Thomsen M.D.; Jeff Ellard; Jon A. Schwartz; Kathy Nolan

doi:10.1117/12.312305

1 July 1998 Chronology of healing events in pulsed CO₂ laser skin resurfacing in fuzzy rat

Sharon L. Thomsen M.D., Jeff Ellard, Jon A. Schwartz, Kathy Nolan

Proceedings Volume 3245, Lasers in Surgery: Advanced Characterization, Therapeutics, and Systems VIII; (1998) https://doi.org/10.1117/12.312305
Event: BiOS '98 International Biomedical Optics Symposium, 1998, San Jose, CA, United States

Abstract

Qualitative and quantitative histopathologic procedures were used to study the chronology of healing and mechanism(s) of wrinkle removal using pulsed CO2 laser irradiation. Lesions placed on 'Fuzzy' rat skin were examined pathologically at 0, 2 and 10 days and 2, 4, 8 and 12 weeks. Re-epithelialization began before 2 days and was complete by 10 days. Lethal thermal damage of the epidermis and superficial dermis led to necrosis and slough of the necrotic tissue. Fibrous dermal scar formation was well established at 10 days and, over the next 10 weeks the scar matured and contracted. The proposed mechanisms of wrinkle removal are (1) lethal thermal damage to the upper layers of the skin, (2) slough of the necrotic tissue and (3) re-epithelialization and (4) fibrous scar formation producing a smooth skin surface.

Citation Download Citation

Sharon L. Thomsen M.D., Jeff Ellard, Jon A. Schwartz, and Kathy Nolan "Chronology of healing events in pulsed CO₂ laser skin resurfacing in fuzzy rat", Proc. SPIE 3245, Lasers in Surgery: Advanced Characterization, Therapeutics, and Systems VIII, (1 July 1998); https://doi.org/10.1117/12.312305

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