Optical and morphological investigation of hair of patients with Chediak Higashi syndrome

Narahari V. Joshi; Jose Goyo-Rivas

doi:10.1117/12.306061

24 April 1998 Optical and morphological investigation of hair of patients with Chediak Higashi syndrome

Narahari V. Joshi, Jose Goyo-Rivas

Proceedings Volume 3251, Coherence Domain Optical Methods in Biomedical Science and Clinical Applications II; (1998) https://doi.org/10.1117/12.306061
Event: BiOS '98 International Biomedical Optics Symposium, 1998, San Jose, CA, United States

Abstract

The Chediak-Higashi syndrome (CHS) is a rare disease and is very often observed in a single family. In Venezuelan Los Andes area, its appearance is not uncommon. One of the peculiar aspects of CHS patients is the color, texture and structure of the hairs. We have, therefore, investigated structure, morphology and composition of hairs and compared those properties with that of normal human subject grown in the same geographical region. A few hairs were cut along its length and their fluorescence was investigated. For CHS patients, dark patches were observed. Investigations of chemical compositions of these regions were carried out of using Energy Dispersive Analysis and it was found the presence of Na, K and Ca ions. Fluorescence spectral studies were carried out at room temperature. Observed spectra reveal two peaks, however, those were not useful for positive identification of CHS.

Citation Download Citation

Narahari V. Joshi and Jose Goyo-Rivas "Optical and morphological investigation of hair of patients with Chediak Higashi syndrome", Proc. SPIE 3251, Coherence Domain Optical Methods in Biomedical Science and Clinical Applications II, (24 April 1998); https://doi.org/10.1117/12.306061

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