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19 June 1998 Role of speckles in laser Doppler flowmetry
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Proceedings Volume 3252, Optical Diagnostics of Biological Fluids III; (1998)
Event: BiOS '98 International Biomedical Optics Symposium, 1998, San Jose, CA, United States
A theory is presented that allows for the prediction of the power of the photocurrent fluctuations in laser Doppler blood flowmetry (LDBFM). The method is complementary to the Monte Carlo simulation method which is only capable of predicting the shape of the Doppler spectrum. The input data required for application of the theory are the angular distribution of the detected photons and the relative amount of Doppler shifted photons. The consequences of the speckle dynamics for the various modes of LDBFM are discussed. The speckle behavior is particularly important in those cases where the photodetector is directly exposed to the light scattered back from the tissue, as found in a certain setup of laser Doppler imaging (LDI). In that case, the optical properties of the tissue govern the size of the speckles. Hence, the type of tissue affects the instrumental response through the speckles in an independent way. In this paper, this effect has been quantified for a number of typical tissues. The speckle effect not only influences the overall response of the instrument in a strong manner, but also its sensitivity to motion at various depths. The speckle related variation of the instrumental response may be suppressed when a sufficiently wide beam is used.
© (1998) COPYRIGHT Society of Photo-Optical Instrumentation Engineers (SPIE). Downloading of the abstract is permitted for personal use only.
Wiendelt Steenbergen and Frits F. M. de Mul "Role of speckles in laser Doppler flowmetry", Proc. SPIE 3252, Optical Diagnostics of Biological Fluids III, (19 June 1998);


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