Development of a DNA biochip for gene diagnosis

Tuan Vo-Dinh; Alan L. Wintenberg; M. Nance Ericson; Narayana R. Isola; Jean Pierre Alarie

doi:10.1117/12.308046

1 May 1998 Development of a DNA biochip for gene diagnosis

Tuan Vo-Dinh, Alan L. Wintenberg, M. Nance Ericson, Narayana R. Isola, Jean Pierre Alarie

Proceedings Volume 3253, Biomedical Sensing and Imaging Technologies; (1998) https://doi.org/10.1117/12.308046
Event: BiOS '98 International Biomedical Optics Symposium, 1998, San Jose, CA, United States

Abstract

We describe a biochip based on an integrated circuit photodiode array for use in medical diagnostics. The biochip is a self-contained device which has photosensors, amplifiers, discriminators and logic circuitry on board. The development and evaluation of various microchip system components of the genosensor are discussed. The performance of the DNA biochip device is illustrated with fluorescence detection of DNA probes specific to gene fragments of the human immuno-deficiency virus 1 system. The usefulness and potential to the DNA biochip technology for rapid and cost- effective medical diagnostics is discussed.

Citation Download Citation

Tuan Vo-Dinh, Alan L. Wintenberg, M. Nance Ericson, Narayana R. Isola, and Jean Pierre Alarie "Development of a DNA biochip for gene diagnosis", Proc. SPIE 3253, Biomedical Sensing and Imaging Technologies, (1 May 1998); https://doi.org/10.1117/12.308046

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