In-vivo determination of myocardial pH during regional ischemia using near-infrared spectroscopy

Songbiao Zhang; Babs R. Soller

doi:10.1117/12.306076

24 April 1998 In-vivo determination of myocardial pH during regional ischemia using near-infrared spectroscopy

Songbiao Zhang, Babs R. Soller

Proceedings Volume 3257, Infrared Spectroscopy: New Tool in Medicine; (1998) https://doi.org/10.1117/12.306076
Event: BiOS '98 International Biomedical Optics Symposium, 1998, San Jose, CA, United States

Abstract

pH electrodes have been used during open heart surgery to ensure adequate delivery of blood and oxygen to the myocardium during the surgical procedure. The electrodes are cumbersome and suffer from motion artifacts. Near infrared spectroscopy was evaluated as a noninvasive method of measuring myocardial pH during regional ischemia in seven beating dog hearts. Two pH microelectrodes were implanted in the distribution area of the left anterior descending (LAD) coronary artery. The LAD was occluded to stop the myocardial blood flow and to initialize regional ischemia. Ischemia was maintained for 20 minutes before the LAD was released to resume blood flow. A fiber-optic probe was used to collect the reflected NIR light over the spectral region of 575 nm to 1100 nm from the heart muscle. Partial least-squares multivariate calibration technique was applied to relate the myocardial pH changes to the NIR spectral changes in the region of 700 to 1100 nm. Calibration models based on data collected on each individual dog heart had an average of 7 factors with an R² of 0.84. The standard error of prediction (SEP) averaged 0.09 pH units for a mean pH change of 0.73 pH units, adequate for monitoring pH changes during cardiac surgery.

Citation Download Citation

Songbiao Zhang and Babs R. Soller "In-vivo determination of myocardial pH during regional ischemia using near-infrared spectroscopy", Proc. SPIE 3257, Infrared Spectroscopy: New Tool in Medicine, (24 April 1998); https://doi.org/10.1117/12.306076

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