Rapid clinical diagnostics assays using injection-molded planar waveguides

James N. Herron; Hsu-Kun Wang; Allen H. Terry; Jacob D. Durtschi; Lyndon Tan; Mark E. Astill; Richard S. Smith; Douglas A. Christensen

doi:10.1117/12.307322

10 April 1998 Rapid clinical diagnostics assays using injection-molded planar waveguides

James N. Herron, Hsu-Kun Wang, Allen H. Terry, Jacob D. Durtschi, Lyndon Tan, Mark E. Astill, Richard S. Smith, Douglas A. Christensen

Author Affiliations +

Proceedings Volume 3259, Systems and Technologies for Clinical Diagnostics and Drug Discovery; (1998) https://doi.org/10.1117/12.307322
Event: BiOS '98 International Biomedical Optics Symposium, 1998, San Jose, CA, United States

Abstract

The goal of our research program is to develop an evanescent wave immunoassay system that can be used in point-of-care and critical care settings. Several key attributes are required to accomplish this goal: (1) the assay system should be at least as sensitive as present day immunoassays; (2) assay time should be 5 minutes or less; (3) the assay protocol should be relatively simple; (4) the sensor should be capable of performing more than one assay on a single specimen; (5) the assay system should be able to accommodate specimens such as serum, plasma and whole blood; and (6) the sensor should be an inexpensive, disposable cartridge. Our laboratory has developed an injection-molded planar waveguide sensor that meets most, if not all, of these attributes. This sensor has been evaluated in a number of different immunoassays for analytes such as bovine serum albumin, human chorionic gonadotrophin, creatine phosphokinase MB and cardiac troponin I.

Citation Download Citation

James N. Herron, Hsu-Kun Wang, Allen H. Terry, Jacob D. Durtschi, Lyndon Tan, Mark E. Astill, Richard S. Smith, and Douglas A. Christensen "Rapid clinical diagnostics assays using injection-molded planar waveguides", Proc. SPIE 3259, Systems and Technologies for Clinical Diagnostics and Drug Discovery, (10 April 1998); https://doi.org/10.1117/12.307322

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