Cooperative effects of photosensitized cell killing

Jostein Dahle; Even Angel-Petersen; Saulius Bagdonas; Harald B. Steen; Johan Moan

doi:10.1117/12.339127

3 February 1999 Cooperative effects of photosensitized cell killing

Jostein Dahle, Even Angel-Petersen, Saulius Bagdonas, Harald B. Steen, Johan Moan

Proceedings Volume 3563, Photochemotherapy of Cancer and Other Diseases; (1999) https://doi.org/10.1117/12.339127
Event: BiOS Europe '98, 1998, Stockholm, Sweden

Abstract

MDCK II cells in colonies of eight cells and in confluent monolayers were treated with two different sensitizers and blue light. In both cases cooperation between the treated cells were detected. Cells photosensitized with Photofrin died by necrosis after irradiation, while cells photosensitized with tetra(3-hydroxyphenyl)porphyrin died by apoptosis. The cooperative interactions between the cells are contrary to one of the fundamental paradigms of radiation biology, namely that the targets of radiation are independent of each other.

Citation Download Citation

Jostein Dahle, Even Angel-Petersen, Saulius Bagdonas, Harald B. Steen, and Johan Moan "Cooperative effects of photosensitized cell killing", Proc. SPIE 3563, Photochemotherapy of Cancer and Other Diseases, (3 February 1999); https://doi.org/10.1117/12.339127

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