Use of scanning Doppler velocimetry to monitor vascular changes during photodynamic therapy

Victor H. Fingar; Thomas Jeffery Wieman M.D.; Scott W. Taber M.D.; Pavan Singh; Stephen J. Kempf Jr.; Cathy G. Pietsch; Claudio Maldonado

doi:10.1117/12.351516

6 July 1999 Use of scanning Doppler velocimetry to monitor vascular changes during photodynamic therapy

Victor H. Fingar, Thomas Jeffery Wieman M.D., Scott W. Taber M.D., Pavan Singh, Stephen J. Kempf Jr., Cathy G. Pietsch, Claudio Maldonado

Author Affiliations +

Proceedings Volume 3592, Optical Methods for Tumor Treatment and Detection: Mechanisms and Techniques in Photodynamic Therapy VIII; (1999) https://doi.org/10.1117/12.351516
Event: BiOS '99 International Biomedical Optics Symposium, 1999, San Jose, CA, United States

Abstract

We are investigating the use of Scanning Doppler Velocimetry to evaluate changes in tissue perfusion that occur during Photodynamic Therapy (PDT). In initial studies, this technique was used to assess changes in tissue perfusion in mice given PDT using Photofrin, Purlytin, or Lutrin. There was a rapid and complete loss of perfusion in both normal tissue and tumor in animals given PDT using Photofrin. Using Purlytin, there was immediate loss of perfusion at the tumor site. For PDT using Lutrin, there was a lot of perfusion in the tumor with relatively no change in the surrounding normal skin, confirming the high degree of selectivity of PDT with this photosensitizer. These reductions in persistent through at least 24 h after PDT.

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Victor H. Fingar, Thomas Jeffery Wieman M.D., Scott W. Taber M.D., Pavan Singh, Stephen J. Kempf Jr., Cathy G. Pietsch, and Claudio Maldonado "Use of scanning Doppler velocimetry to monitor vascular changes during photodynamic therapy", Proc. SPIE 3592, Optical Methods for Tumor Treatment and Detection: Mechanisms and Techniques in Photodynamic Therapy VIII, (6 July 1999); https://doi.org/10.1117/12.351516

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