Calf muscle blood flow and oxygen consumption measured with near-infrared spectroscopy during venous occlusion

Lelia Adelina Paunescu; Claudia Casavola; Maria-Angela Franceschini; Sergio Fantini; Lew Winter; Jin Kim; Debra Wood; Enrico Gratton

doi:10.1117/12.356790

15 July 1999 Calf muscle blood flow and oxygen consumption measured with near-infrared spectroscopy during venous occlusion

Lelia Adelina Paunescu, Claudia Casavola, Maria-Angela Franceschini, Sergio Fantini, Lew Winter, Jin Kim, Debra Wood, Enrico Gratton

Author Affiliations +

Proceedings Volume 3597, Optical Tomography and Spectroscopy of Tissue III; (1999) https://doi.org/10.1117/12.356790
Event: BiOS '99 International Biomedical Optics Symposium, 1999, San Jose, CA, United States

Abstract

We present non-invasive measurements of the calf muscle blood flow (BF) and oxygen consumption (OC) by near-infrared spectroscopy. We used a frequency domain tissue oximeter (modulation frequency: 110 MHz, wavelengths: 758 and 830 nm) to measure in real time (acquisition time: 0.64 s) the hemoglobin concentration and saturation. After 1-min of baseline acquisition, we achieved venous occlusion by inflating a pneumatic cuff on the subjectÕs thigh to a pressure of 60 mmHg. The cuff was released after 1 min. The baseline/inflation/release procedure was repeated 3 times to verify reproducibility. We calculated the BF and OC from the initial rate of increase of the total hemoglobin and deoxy-hemoglobin concentration immediately after the onset of venous occlusion. We examined 8 healthy subjects and 18 patients affected by peripheral vascular disease (PVD) in 1 or 2 legs to investigate whether muscle BF and OC at rest can be useful indicators of vascular insufficiency. In healthy legs, we obtained average values of BF=0.73 ml/(100ml)/min and OC=0.10 ml/(100g)/min. The corresponding average values found in legs affected by PVD are BF=1.39 ml/(100ml)/min and OC=0.16 ml/(100g)/min. The ranges of values of BF and OC measured in the healthy legs broadly overlap with the corresponding ranges measured in the PVD legs.

Citation Download Citation

Lelia Adelina Paunescu, Claudia Casavola, Maria-Angela Franceschini, Sergio Fantini, Lew Winter, Jin Kim, Debra Wood, and Enrico Gratton "Calf muscle blood flow and oxygen consumption measured with near-infrared spectroscopy during venous occlusion", Proc. SPIE 3597, Optical Tomography and Spectroscopy of Tissue III, (15 July 1999); https://doi.org/10.1117/12.356790

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