In-vivo evaluation of layered scattering coefficients and refractive indices with OCT

Alexander R. Knuettel; Martin Boehlau-Godau; Michael Rist; Paul Welker; Uwe Gogolin; Christian Kugler

doi:10.1117/12.356823

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15 July 1999 In-vivo evaluation of layered scattering coefficients and refractive indices with OCT

Alexander R. Knuettel, Martin Boehlau-Godau, Michael Rist, Paul Welker, Uwe Gogolin, Christian Kugler

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Proceedings Volume 3597, Optical Tomography and Spectroscopy of Tissue III; (1999) https://doi.org/10.1117/12.356823
Event: BiOS '99 International Biomedical Optics Symposium, 1999, San Jose, CA, United States

Abstract

Besides morphological images created by optical coherence tomography (OCT), further parameters are evaluated in skin tissue under in vivo conditions. Scattering coefficients and refractive indices may support tissue characterization for research and diagnostic purposes in cosmetics / pharmacy and medicine, respectively. The known Klett algorithm15 has been applied for retrieval of scattering coefficients. To permit refractive index evaluation, the sample arm of our OCT setup has been arranged to minimize mechanical adjustment of a lens within the objective. A corresponding simple algorithm has been derived. Both parameters have been measured in layered structures in skin like stratum comeum, epidermis and dermis. Significant water content in a localized sweatgland duct has been observed by refractive index evaluation.

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Alexander R. Knuettel, Martin Boehlau-Godau, Michael Rist, Paul Welker, Uwe Gogolin, and Christian Kugler "In-vivo evaluation of layered scattering coefficients and refractive indices with OCT", Proc. SPIE 3597, Optical Tomography and Spectroscopy of Tissue III, (15 July 1999); https://doi.org/10.1117/12.356823

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