Determination of burn depth by polarization-sensitive optical coherence tomography

Shyam M. Srinivas; Johannes F. de Boer; Boris Hyle Park; Kurosh Keikhanzadeh; Leah Huang; Zhongping Chen; J. Stuart Nelson M.D.

doi:10.1117/12.347475

30 April 1999 Determination of burn depth by polarization-sensitive optical coherence tomography

Shyam M. Srinivas, Johannes F. de Boer, Boris Hyle Park, Kurosh Keikhanzadeh, Leah Huang, Zhongping Chen, J. Stuart Nelson M.D.

Author Affiliations +

Proceedings Volume 3598, Coherence Domain Optical Methods in Biomedical Science and Clinical Applications III; (1999) https://doi.org/10.1117/12.347475
Event: BiOS '99 International Biomedical Optics Symposium, 1999, San Jose, CA, United States

Abstract

Burn depth assessment is a key step guiding the treatment plan in patients who have sustained thermal injuries. We have developed a technique, polarization sensitive optical coherence tomography (PS-OCT), to provide the physician with a quantitative estimate of actual burn depth. We generated burns of various depths by contacting rates with a brass rod preheated to 75 degrees for 5, 15, or 30 seconds. PS-OCT imags birefringence in biological tissue, through the depth resolved changes in the polarization state of light propagated and reflected from the sample. Preliminary result are presented that show a correlation between the loss of birefringence due to thermal injury and the actual burn depth determined by histological analysis. PS-OCT is a noninvasive technique which potentially can give physicians the accuracy to formulate the best treatment plan for burn patients.

Citation Download Citation

Shyam M. Srinivas, Johannes F. de Boer, Boris Hyle Park, Kurosh Keikhanzadeh, Leah Huang, Zhongping Chen, and J. Stuart Nelson M.D. "Determination of burn depth by polarization-sensitive optical coherence tomography", Proc. SPIE 3598, Coherence Domain Optical Methods in Biomedical Science and Clinical Applications III, (30 April 1999); https://doi.org/10.1117/12.347475

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