Spectral properties and biological applications of solvatochromic Dapoxyl dyes

Zhenjun Diwu; Yixin Lu; Cailan Zhang; Dieter H. Klaubert; Richard P. Haugland

doi:10.1117/12.347529

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3 May 1999 Spectral properties and biological applications of solvatochromic Dapoxyl dyes

Zhenjun Diwu, Yixin Lu, Cailan Zhang, Dieter H. Klaubert, Richard P. Haugland

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Proceedings Volume 3602, Advances in Fluorescence Sensing Technology IV; (1999) https://doi.org/10.1117/12.347529
Event: BiOS '99 International Biomedical Optics Symposium, 1999, San Jose, CA, United States

Abstract

Fluorescent molecules, whose spectra or quantum yields are sensitive to their surrounding environments, are valuable in the study of heterogeneous media, organized media and biological media, and many fluorescent solvatochromic dyes have been developed for these applications. However, the existing fluorescent solvatochromic dyes either have short absorption and emission wavelengths, low extinction coefficients, low quantum yields or small Stokes shift. We have recently developed solvatochromic Dapoxyl^TM dyes, whose fluorescence maximum shifts to longer wavelengths, and fluorescence quantum yield decreases with increasing solvent polarity. In these molecules, there is a 'push-pull' electron transfer system from the 5-phenyl moiety to the 2-phenyl ring. The compounds show strong solvent-dependent fluorescence that is well correlated with the empirical solvent polarity parameter E_T(30). These dyes have also shown long emission wavelengths, high extinction coefficients, high quantum yields and large Stokes shifts. Their biological applications will also be discussed.

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Zhenjun Diwu, Yixin Lu, Cailan Zhang, Dieter H. Klaubert, and Richard P. Haugland "Spectral properties and biological applications of solvatochromic Dapoxyl dyes", Proc. SPIE 3602, Advances in Fluorescence Sensing Technology IV, (3 May 1999); https://doi.org/10.1117/12.347529

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