Combining biochemical sensing and imaging on a microscopic scale

Peng Zhang; Weihong Tan

doi:10.1117/12.350622

17 June 1999 Combining biochemical sensing and imaging on a microscopic scale

Peng Zhang, Weihong Tan

Proceedings Volume 3607, Scanning and Force Microscopies for Biomedical Applications; (1999) https://doi.org/10.1117/12.350622
Event: BiOS '99 International Biomedical Optics Symposium, 1999, San Jose, CA, United States

Abstract

Optical fiber sensors have been widely used in analytical chemistry, physiology, biology and other areas. With the development of sub-micron chemical fiber optical sensors with millisecond response times, it becomes possible to combine the capacity of biochemical sensing with well- established scanning probe microscopies, such as AFM, NSOM. Using near-field optical probe and microscopy, we can simultaneously obtain topographic and optical images of a variety of samples. By implementing a commercial NSOM system with the chemical sensor, we are developing an optical fiber-based scanning sensor microscope using evanescent wave excitation and chemically modified optical fiber probes. Further application of such microscope will be discussed. The major advantage of this microscopic imaging technique is its potential capability of topographic and biochemical imaging of a sample.

Citation Download Citation

Peng Zhang and Weihong Tan "Combining biochemical sensing and imaging on a microscopic scale", Proc. SPIE 3607, Scanning and Force Microscopies for Biomedical Applications, (17 June 1999); https://doi.org/10.1117/12.350622

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