Surface-enhanced Raman spectroscopy for the in-vitro and ex-vivo detection of excitatory amino acids

D. Patrick O'Neal; Massoud Motamedi; Jefferson Chen M.D.; Gerard L. Cote

doi:10.1117/12.345404

9 April 1999 Surface-enhanced Raman spectroscopy for the in-vitro and ex-vivo detection of excitatory amino acids

D. Patrick O'Neal, Massoud Motamedi, Jefferson Chen M.D., Gerard L. Cote

Proceedings Volume 3608, Biomedical Applications of Raman Spectroscopy; (1999) https://doi.org/10.1117/12.345404
Event: BiOS '99 International Biomedical Optics Symposium, 1999, San Jose, CA, United States

Abstract

Traditionally methods for the detection of excitatory amino acids, which have been linked to secondary injury following head trauma, can be excessively time consuming clinically. A near real-time measurement system could provide clinical information in anticipation of pharmaceutical intervention for head injured patients. Our studies have shown that surface-enhanced Raman spectroscopy (SERS) with silver colloids has the ability to measure physiological concentrations of in vitro excitatory amino acids using short scan times. Employing a damage model for ischemia, preliminary ex vivo rat extracellular grain fluid analysis shows an intriguing correlation between SERS spectral features and expected Glutamate concentration fluctuations following head injuries.

Citation Download Citation

D. Patrick O'Neal, Massoud Motamedi, Jefferson Chen M.D., and Gerard L. Cote "Surface-enhanced Raman spectroscopy for the in-vitro and ex-vivo detection of excitatory amino acids", Proc. SPIE 3608, Biomedical Applications of Raman Spectroscopy, (9 April 1999); https://doi.org/10.1117/12.345404

ACCESS THE FULL ARTICLE

INSTITUTIONAL
Select your institution to access the SPIE Digital Library.

SELECT YOUR INSTITUTION

PERSONAL
Sign in with your SPIE account to access your personal subscriptions or to use specific features such as save to my library, sign up for alerts, save searches, etc.

PERSONAL SIGN IN

No SPIE Account? Create one

PURCHASE THIS CONTENT

SUBSCRIBE TO DIGITAL LIBRARY

50 downloads per 1-year subscription

Members: $195

Non-members: $335 ADD TO CART

25 downloads per 1 - year subscription

Members: $145

Non-members: $250 ADD TO CART

PURCHASE SINGLE ARTICLE

Includes PDF, HTML & Video, when available