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21 May 1999 Measurement of hippocampal volume changes in serial MRI scans
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We present a new method for the detection and measurement of volume changes in human hippocampi in serial Magnetic Resonance Imaging (MRI). The method follows a two-stage approach: (1) precise co-registration and intensity matching of the initial (baseline) and follow-up scan, and (2) refinement and segmentation propagation of the hippocampi outlines drawn in the baseline scan by an expert observer to the matched scan (co-registered and intensity matched follow- up scan of the time series). The first step is performed using MRreg, a rigid registration tool based on cross-correlation and intensity matching, and the second step makes use of the concept of active contour models for tracking the hippocampi outlines in the time series.
© (1999) COPYRIGHT Society of Photo-Optical Instrumentation Engineers (SPIE). Downloading of the abstract is permitted for personal use only.
Julia Anne Schnabel, Louis Lemieux, U. C. Wieshmann, and Simon Robert Arridge "Measurement of hippocampal volume changes in serial MRI scans", Proc. SPIE 3661, Medical Imaging 1999: Image Processing, (21 May 1999);

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