Evaluation of angiograms obtained from a laser-based x-ray source in DESA regime

Ernest M. Scalzetti; Andrzej Krol; George M. Gagne; Ted T. Renvyle; Charles C. Chamberlain; Jean-Claude Kieffer; Zhiming Jiang; Jianfan Yu

doi:10.1117/12.349640

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24 May 1999 Evaluation of angiograms obtained from a laser-based x-ray source in DESA regime

Ernest M. Scalzetti, Andrzej Krol, George M. Gagne, Ted T. Renvyle, Charles C. Chamberlain, Jean-Claude Kieffer, Zhiming Jiang, Jianfan Yu

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Proceedings Volume 3663, Medical Imaging 1999: Image Perception and Performance; (1999) https://doi.org/10.1117/12.349640
Event: Medical Imaging '99, 1999, San Diego, CA, United States

Abstract

Contrast resolution of angiograms created using a laser-based x-ray source in Dual Energy Subtraction Angiography (DESA) regime has been investigated. It has been compared to contrast in angiograms obtained using an x-ray tube-based clinical angiography unit in DSA mode. Contrast detail phantoms and rats with opacified vascular structures were imaged. A table top terawatt laser was used (10¹⁹ Wcm^-2, 150 fs or 450 fs per pulse). For Iodine contrast agent, an Iodine filter was used with the BaF₂ target to obtain images with mean x-rays energy below the Iodine K-edge. La target and La filter was used to obtain images with mean x-rays energy above the Iodine K-edge. For Ba contrast agent, a Nd filter was used with the Nd target to obtain images with mean x-rays energy below the Ba K-edge. Gd target and Nd filter was used to obtain images with mean x-rays energy above the Barium K-edge. It has been determined that the laser-based DESA with properly selected targets demonstrates better contrast than a standard x-ray tube-based DSA angiography. We conclude that laser-based x-ray source has promise for angiography in DESA regime providing that sufficient x-ray flux can be delivered by the laser.

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Ernest M. Scalzetti, Andrzej Krol, George M. Gagne, Ted T. Renvyle, Charles C. Chamberlain, Jean-Claude Kieffer, Zhiming Jiang, and Jianfan Yu "Evaluation of angiograms obtained from a laser-based x-ray source in DESA regime", Proc. SPIE 3663, Medical Imaging 1999: Image Perception and Performance, (24 May 1999); https://doi.org/10.1117/12.349640

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