Optical coherence tomography in differential diagnosis of skin pathology

Natalia D. Gladkova; Galina P. Petrova; Elena Derpaluk; Nikolai K. Nikulin; Ludmila Snopova; Yuri Chumakov; Felix I. Feldchtein; Valentin M. Gelikonov; Grigory V. Gelikonov; Roman V. Kuranov

doi:10.1117/12.386243

17 May 2000 Optical coherence tomography in differential diagnosis of skin pathology

Natalia D. Gladkova, Galina P. Petrova, Elena Derpaluk, Nikolai K. Nikulin, Ludmila Snopova, Yuri Chumakov, Felix I. Feldchtein, Valentin M. Gelikonov, Grigory V. Gelikonov, Roman V. Kuranov

Author Affiliations +

Proceedings Volume 3907, Lasers in Surgery: Advanced Characterization, Therapeutics, and Systems X; (2000) https://doi.org/10.1117/12.386243
Event: BiOS 2000 The International Symposium on Biomedical Optics, 2000, San Jose, CA, United States

Abstract

The capabilities of optical coherence tomography (OCT) for imaging in vivo of optical patterns of pathomorphological processes in the skin and use of their optical patterns in clinical practice for differential diagnosis of dermatoses are presented. Images of skin tissue 0.8 - 1.5 mm deep were acquired with a resolution of 5, 12 and 20 micrometer using three compact fiber OCT devices developed at the Institute of Applied Physics RAS. The acquisition time of images of skin regions 2 - 6 mm in length was 2 - 4 s. The OCT capabilities were analyzed based on the study of 50 patients with different dermatoses. OCT images were interpreted by comparing with parallel histology. It is shown that OCT can detect in vivo optical patterns of morphological alterations in such general papulous dermatoses as lichen ruber planus and psoriasis, a capability that can be used in differential diagnosis of these diseases. Most informative are OCT images obtained with a resolution of 5 micrometer. The results of our study demonstrate the practical importance of OCT imaging for diagnosis of different dermatoses. OCT is noninvasive and, therefore, makes it possible to perform frequent multifocal examination of skin without any adverse effects.

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Natalia D. Gladkova, Galina P. Petrova, Elena Derpaluk, Nikolai K. Nikulin, Ludmila Snopova, Yuri Chumakov, Felix I. Feldchtein, Valentin M. Gelikonov, Grigory V. Gelikonov, and Roman V. Kuranov "Optical coherence tomography in differential diagnosis of skin pathology", Proc. SPIE 3907, Lasers in Surgery: Advanced Characterization, Therapeutics, and Systems X, (17 May 2000); https://doi.org/10.1117/12.386243

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KEYWORDS

Optical coherence tomography

Skin

Visualization

Tissue optics

Biopsy

Backscatter

Image resolution

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