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15 March 2000BioMEMS applied to the development of cell-based bioassay systems
Biological applications of MEMS technology (bioMEMS) is of increasing interest in the development of miniature and portable instrumentation for cell-based microassays and sensor applications. A major bioMEMS challenge is the physical incorporation of living cells into sensors and diagnostic devices and creation of the environmental conditions conducive for organization of differentiated cells into tissue-like structures. Our work towards these goals is illustrated by a tissue-based bioassay system we are developing based on a miniature cross-flow bioreactor constructed from of an array of cell-filled microchannels integrated into an environmentally-controlled polymer microfluidics manifold. We describe our microchannel array and manifold manufacturing methods and report on the in vitro culture of cell populations in the bioreactor.
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Colin J. H. Brenan, Karel Domansky, Petra Kurzawski, Linda G. Griffith, "BioMEMS applied to the development of cell-based bioassay systems," Proc. SPIE 3912, Micro- and Nanotechnology for Biomedical and Environmental Applications, (15 March 2000); https://doi.org/10.1117/12.379564