BioMEMS applied to the development of cell-based bioassay systems

Colin J. H. Brenan; Karel Domansky; Petra Kurzawski; Linda G. Griffith

doi:10.1117/12.379564

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15 March 2000 BioMEMS applied to the development of cell-based bioassay systems

Colin J. H. Brenan, Karel Domansky, Petra Kurzawski, Linda G. Griffith

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Proceedings Volume 3912, Micro- and Nanotechnology for Biomedical and Environmental Applications; (2000) https://doi.org/10.1117/12.379564
Event: BiOS 2000 The International Symposium on Biomedical Optics, 2000, San Jose, CA, United States

Abstract

Biological applications of MEMS technology (bioMEMS) is of increasing interest in the development of miniature and portable instrumentation for cell-based microassays and sensor applications. A major bioMEMS challenge is the physical incorporation of living cells into sensors and diagnostic devices and creation of the environmental conditions conducive for organization of differentiated cells into tissue-like structures. Our work towards these goals is illustrated by a tissue-based bioassay system we are developing based on a miniature cross-flow bioreactor constructed from of an array of cell-filled microchannels integrated into an environmentally-controlled polymer microfluidics manifold. We describe our microchannel array and manifold manufacturing methods and report on the in vitro culture of cell populations in the bioreactor.

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Colin J. H. Brenan, Karel Domansky, Petra Kurzawski, and Linda G. Griffith "BioMEMS applied to the development of cell-based bioassay systems", Proc. SPIE 3912, Micro- and Nanotechnology for Biomedical and Environmental Applications, (15 March 2000); https://doi.org/10.1117/12.379564

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