Imaging vascular implants with optical coherence tomography

Jennifer Kehlet Barton; Donny B. Dal Ponte; Stuart K. Williams; Bridget K. Ford; Michael R. Descour

doi:10.1117/12.384161

28 April 2000 Imaging vascular implants with optical coherence tomography

Jennifer Kehlet Barton, Donny B. Dal Ponte, Stuart K. Williams, Bridget K. Ford, Michael R. Descour

Proceedings Volume 3915, Coherence Domain Optical Methods in Biomedical Science and Clinical Applications IV; (2000) https://doi.org/10.1117/12.384161
Event: BiOS 2000 The International Symposium on Biomedical Optics, 2000, San Jose, CA, United States

Abstract

Vascular stents and grafts have many proven and promising clinical applications, but also a large number of complications. A focus of current research is the development of biocompatible implants. Evaluation of these devices generally requires a large number of animals due to the need for explanation and histological evaluation of the implant at several time intervals. It would be desirable to use instead a high resolution, in situ assessment method. An in vitro study was performed to determine if OCT could image cell proliferation and thrombus formation on vascular stents and grafts. First, images were taken of explanted stents. The implants were locate din peripheral vessels of a porcine model of atherosclerosis. The images clearly show the vessel response to initial damage, the materials of the implant, extent of intimal cell hyper proliferation, and small platelet aggregates. Next, a tissue engineered graft, which had been sodded with smooth muscle cells and incubated in a bioreactor, was evaluated. Cross-section images showed the pores of the polymer material and the layer of smooth muscle cells beginning to invade the graft material. For comparison, in vitro 20 MHz IVUS images of the same grafts were obtained. A catheter was designed for intravascular imaging. The 2.3 mm diameter catheter contains a fiber with GRIN lens and right angle prism, a monorail guidewire, and a novel positioning wire that can be protruded to push the catheter against the vessel wall, potentially eliminating the need for saline flush. Preliminary in vitro results with this catheter are encouraging.

Citation Download Citation

Jennifer Kehlet Barton, Donny B. Dal Ponte, Stuart K. Williams, Bridget K. Ford, and Michael R. Descour "Imaging vascular implants with optical coherence tomography", Proc. SPIE 3915, Coherence Domain Optical Methods in Biomedical Science and Clinical Applications IV, (28 April 2000); https://doi.org/10.1117/12.384161

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