Noninvasive detection and staging of oral cancer in vivo with confocal optoacoustic tomography

Elena V. Savateeva; Alexander A. Karabutov; Massoud Motamedi; Brent A. Bell; Richard M. Johnigan; Alexander A. Oraevsky

doi:10.1117/12.386341

19 May 2000 Noninvasive detection and staging of oral cancer in vivo with confocal optoacoustic tomography

Elena V. Savateeva, Alexander A. Karabutov, Massoud Motamedi, Brent A. Bell, Richard M. Johnigan, Alexander A. Oraevsky

Author Affiliations +

Proceedings Volume 3916, Biomedical Optoacoustics; (2000) https://doi.org/10.1117/12.386341
Event: BiOS 2000 The International Symposium on Biomedical Optics, 2000, San Jose, CA, United States

Abstract

Confocal opto-acoustic transducer (COAT) was developed and applied for detection of early stages of squamous cell carcinoma in hamster model of oral cancer. COAT is a novel imaging modality with optical and acoustic lens utilized for detecting in-depth opto-acoustic front surface transducer is an improved lateral resolution of 60-micrometers . The bandwidth of the confocal opto-acoustic transducer is more than 100 MHz. Therefore, in-depth axial resolution defined by the laser pulse duration and detection system equals 15-micrometers . Imaging was performed at the wavelength of the Nd:YAG laser second harmonic, which provided sufficient depth of monitoring and significant tissue contrast. Correlation of the opto- acoustic images with H and E histology sections in control animals and in animals treated with carcinogenic agent, DMBA, confirmed previous findings that early cancer lesions invisible by the naked eye may be detected with the opto- acoustic tomography. Compact design of COAT allows, in principle, application of the opto-acoustic imaging in any organ of the human digestive system.

Citation Download Citation

Elena V. Savateeva, Alexander A. Karabutov, Massoud Motamedi, Brent A. Bell, Richard M. Johnigan, and Alexander A. Oraevsky "Noninvasive detection and staging of oral cancer in vivo with confocal optoacoustic tomography", Proc. SPIE 3916, Biomedical Optoacoustics, (19 May 2000); https://doi.org/10.1117/12.386341

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