Diagnosis and prognosis of tissue pathologies by Raman microspectroscopy: an application to human thyroid tumors

Michel Manfait; Philippe Lamaze; Hasnae Lamfarraj; Michel Pluot; Ganesh D. Sockalingum

doi:10.1117/12.384936

8 May 2000 Diagnosis and prognosis of tissue pathologies by Raman microspectroscopy: an application to human thyroid tumors

Michel Manfait, Philippe Lamaze, Hasnae Lamfarraj, Michel Pluot, Ganesh D. Sockalingum

Author Affiliations +

Proceedings Volume 3918, Biomedical Spectroscopy: Vibrational Spectroscopy and Other Novel Techniques; (2000) https://doi.org/10.1117/12.384936
Event: BiOS 2000 The International Symposium on Biomedical Optics, 2000, San Jose, CA, United States

Abstract

This study shows a first application of Raman microspectroscopy to the study of thyroid tissue samples classified as carcinomas, adenomas and nodules. Treatment of the Raman data using statistical methods show that it is possible to classify most of the samples in accord with the pathological examinations. Furthermore, Raman spectral image based on specific bands or frequencies defined as 'functional descriptors' allow to construct maps of micro- zones of such tissues. Such maps can be useful as complementary tools for tissue diagnosis and prognosis, since they carry molecular information important to such ends.

Citation Download Citation

Michel Manfait, Philippe Lamaze, Hasnae Lamfarraj, Michel Pluot, and Ganesh D. Sockalingum "Diagnosis and prognosis of tissue pathologies by Raman microspectroscopy: an application to human thyroid tumors", Proc. SPIE 3918, Biomedical Spectroscopy: Vibrational Spectroscopy and Other Novel Techniques, (8 May 2000); https://doi.org/10.1117/12.384936

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